BEERSHEBA, Israel (AP) — Israel’s defense minister threatened Iran’s supreme leader on Thursday after the latest missile barrage from Iran damaged the main hospital in southern Israel and hit several other residential buildings near Tel Aviv. Israel meanwhile struck a heavy water reactor that is part of Iran’s nuclear program.

Calling out President Donald Trump directly, the Supreme Leader added: “The U.S. President threatens us. With his absurd rhetoric, he demands that the Iranian people surrender to him. They should make threats against those who are afraid of being threatened. The Iranian nation isn’t frightened by such threats.”