A new prime editing sensor library targeting p53 mutations allowed scientists to interrogate thousands of tumor genotypes as they arose in endogenous contexts.

Moments after birth, a baby takes a first breath as the placenta, which has served as the fetus’ lungs during gestation, transfers responsibility to the baby's own organs. However, for patients born ...

Three-dimensional cell culture models including organoids enable researchers to recapitulate complex biological processes and tissue characteristics in a controllable in vitro setting. However, ...

CRISPR-carrying lipid nanoparticles enabled researchers to correct a rare nonsense mutation in the lungs of a cystic fibrosis ...

Yet, despite the cost savings that virtual platforms offered for researchers, scientists flew to conferences in throngs once ...

Researchers can build models to predict gene expression by detecting and differentiating between cytosine methylation and hydroxymethylation marks in the genome. DNA methylation is an epigenetic ...

Mariella is an assistant editor at The Scientist. She has a background in neuroscience, and her work has appeared in Drug Discovery News and Massive Science. View full profile. Learn about our ...

Building on the success of CAR T cell therapy for treating blood cancers, researchers are developing NK cell therapies that employ the natural ability of these immune cells to eliminate abnormal cells ...

Submit your new product for a chance at being selected for a coveted spot in The Scientist’s 2024 competition. The Scientist’s Top 10 Innovations competition showcases the most transformative and ...

Immediately, they could tell that the synthetic TF shook up neuron physiology. Neurons in the prefrontal cortex, a brain ...

Using positron emission tomography (PET) to analyze cancerous brain tissue is complicated by heterogeneity in the tumor microenvironment (TME). Many potential radiotracer targets are shared between ...