Death by Fat. In tauopathy neurons (gray), downregulated AMP kinase causes lipid droplets (LDs, yellow) to accumulate, ...
Destructive Relief. In the proposed strain relief mechanism, left-twisted tau fibrils bind D-peptides, which initially adopt ...
Numerous studies have cast TREM2-expressing microglia as good guys in the Alzheimer’s brain, but new research suggests some ...
To allow for the local translation of proteins that suit the ever-changing needs of the axon, neurons must ship transcripts from the soma to their outermost reaches. For thousands of these mRNAs, ...
A new study adds to the evidence that a class of diabetes drugs could help Parkinson’s patients, even if only a little. In the April 4 New England Journal of Medicine, researchers led by Olivier ...
C-terminal fragments of amyloid precursor protein have been blamed for endolysosomal dysfunction in Alzheimer’s disease. Now, scientists led by Wim Annaert at KU Leuven, Belgium, claim that’s because ...
Microglia seem to play a hand in every aspect of Alzheimer’s pathogenesis, from the seeding and clearing of plaques to the traveling of tau to the dying of neurons. Scientists are pursuing ...
Among plasma biomarkers for Alzheimer’s disease, p-Tau217 stands tall as having the highest diagnostic accuracy. Now, in the March 23 Nature Communications, researchers led by Przemyslaw Kac, Thomas ...
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