East Palestine is a village in northeastern Columbiana County, Ohio, United States. The population was 4,761 at the 2020 census. Located on the state's border with Pennsylvania, East Palestine is about 20 miles south of Youngstown and 40 miles northwe…East Palestine is a village in northeastern Columbiana County, Ohio, United States. The population was 4,761 at the 2020 census. Located on the state's border with Pennsylvania, East Palestine is about 20 miles south of Youngstown and 40 miles northwest of Pittsburgh. It is part of the Salem micropolitan area.
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