As the US weighs joining Israel’s assault on Iran, questions are mounting over whether such an intervention could trigger regime change in Tehran – an outcome that risks splintering the country and sending shockwaves across the region.

An Iranian missile hit the main hospital in southern Israel early Thursday, wounding people and causing “extensive damage” but no serious injuries, the medical facility said. Israeli media aired footage of blown-out windows and heavy black smoke.

Calling out President Donald Trump directly, the Supreme Leader added: “The U.S. President threatens us. With his absurd rhetoric, he demands that the Iranian people surrender to him. They should make threats against those who are afraid of being threatened. The Iranian nation isn’t frightened by such threats.”