A 30-year-old woman was evaluated because of back pain, leg stiffness, and falling. Tone was increased in the legs.

After Covid-19, the global health community must address major gaps in global preparedness, critical capacities needed for a safer and fairer world, and international instruments required for ...

The use of thrombectomy in patients with acute stroke and a large infarct of unrestricted size has not been well studied. We assigned, in a 1:1 ratio, patients with proximal cerebral vessel ...

In patients with immune thrombotic thrombocytopenic purpura (iTTP), autoantibodies against the metalloprotease ADAMTS13 lead to catastrophic microvascular thrombosis. However, the potential ...

“You don’t know what you’re missing till it’s gone” is a truism that certainly applies to taste. It took a pandemic for taste to get attention. Severe acute respiratory syndrome ...

Congenital thrombotic thrombocytopenic purpura (TTP) results from severe hereditary deficiency of ADAMTS13. The efficacy and safety of recombinant ADAMTS13 and standard therapy (plasma-derived ...

A 72-year-old man who had emigrated from Zimbabwe 20 years previously presented with a 17-year history of swelling of the penis, scrotum, and left leg.

A 62-year-old man presented with a 1-month history of muscle aches in the legs and weight loss. Abdominal angiography revealed aneurysms and irregularity of the walls of multiple arteries.

Repeated attempts at endotracheal intubation are associated with increased adverse events in neonates. When clinicians view the airway directly with a laryngoscope, fewer than half of first ...

In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and ...

Worldwide, cryptococcal meningitis kills up to 180,000 persons annually and is the most common cause of nonviral meningitis in the United States. Besides patients with immunosuppression due to ...