Patients with relapsed or refractory hematologic cancers have a poor prognosis. Chimeric antigen receptor (CAR) T-cell therapy as a bridge to allogeneic hematopoietic stem-cell transplantation ...

Subcutaneous administration of the monoclonal antibody L9LS protected adults against controlled Plasmodium falciparum infection in a phase 1 trial. Whether a monoclonal antibody administered ...

Infants were eligible if they were born between 32 weeks 0 days’ and 35 weeks 6 days’ gestation, had been admitted to a neonatal unit, and had intravenous access that had been established for ...

In the year after the elimination of a waiver requirement to prescribe buprenorphine, the number of prescribers increased above the anticipated value, but the number of persons who received the ...

We conducted an open-label, single-group, phase 3 study of exa-cel in patients 12 to 35 years of age with transfusion-dependent β-thalassemia and a β 0 /β 0, β 0 /β 0-like, or non–β 0 /β ...

Current drug-based prevention strategies, such as seasonal malaria chemoprevention in children with the use of sulfadoxine–pyrimethamine and amodiaquine, are operationally challenging to ...

Exagamglogene autotemcel (exa-cel) is a nonviral cell therapy designed to reactivate fetal hemoglobin synthesis by means of ex vivo clustered regularly interspaced short palindromic repeats ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Disclosure forms provided by the authors are available with the full text of this editorial at NEJM.org. From the Global Health Division, Bill and Melinda Gates Foundation (J.M.M.), and the Fred ...

Dr. Jamie Aron (Emergency Medicine): A 27-year-old man was evaluated at this hospital because of leg weakness. The patient had been in his usual state of health until 3 days before the current ...

Most physicians now face the experience of being employees of hospitals or other large organizations. Unionization is a natural consequence of consolidation and the corporatization of health care ...

The autologous cellular therapy exagamglogene autotemcel is generated by editing an erythroid-specific enhancer of BCL11A. Could another site be edited unintentionally? This study gauged the ...